Obesity is a growing problem in the United States that can lead to multiple health complications.

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    Metformin is a medication that normally is used in the treatment of type 2 diabetes mellitus. This medication is in the antihyperglyemic drug class, meaning that it counteracts glucose in the blood.

    While the Food and Drug Administration has not approved metformin for weight loss in the United States, some physicians are starting to utilize this medication in an off-label manner to decrease weight in patients with overweight or obesity. Several studies are underway analyzing the use of metformin for weight loss, and more studies are needed before FDA approval.

    Decreased Hepatic Glucose Production

    Metformin decreases the amount of sugar that is created by the liver, according to findings from the Glaser Obesity Study, conducted by the Glaser Pediatric Research Network. If you haven't eaten in some period of time and your blood sugar becomes too low, your liver can compensate by creating and releasing sugar into the blood. Insulin is then secreted to compensate, and stores this sugar as fat in adipose tissue. When metformin decreases the amount of sugar released by the liver, the pancreas does not have to release extra insulin, thus reducing fat production and storage.

    Decreased Food Intake

    Research has indicated that metformin may have an appetite-suppressing effect, though it is not completely understood why this occurs at the present time, according to the Weight-control Information Network. The network also states that metformin may make you feel satisfied quicker and for a longer period of time than normal.

    Gastrointestinal Side Effects

    Metformin may cause mild gastrointestinal side effects including diarrhea, nausea and vomiting, according to Drugs.com. It is proposed that one possible mechanism of action for the weight-reducing benefit of metformin is simply that because of these mild gastrointestinal side effects people do not feel like eating, notes the Glaser research. If you have excessive or prolonged gastrointestinal upsets while taking metformin, contact your physician as he may need to change your medication.

    Reduced Insulin Resistance

    Metformin creates increased insulin sensitivity by assisting the body in using the blood sugar already present. This process decreases the release of glucagon and glucogenesis to increase blood sugar levels. Because metformin helps the body use blood sugar rather than store it, less fat is created and stored by the body.

    Can metformin be used for weight loss in non diabetics?
    In fact, your doctor might prescribe metformin for weight loss even if you don't have diabetes or prediabetes. This use of metformin is called an off-label use. more
    What is the average weight loss with metformin?
    Results: The mean weight loss in the metformin treated group was 5.8±7.0 kg (5.6±6.5%). Untreated controls gained 0.8±3.5 kg (0.8±3.7%) on average. Patients with severe insulin resistance lost significantly more weight as compared to insulin sensitive patients. more
    How fast is weight loss with metformin?
    Although studies have shown that metformin may help with weight loss, the drug is not a quick-fix solution. According to one long-term study , the weight loss from metformin tends to occur gradually over one to two years. The amount of weight lost also varies from person to person. more
    Is Metformin good for weight loss?
    Conclusion: Metformin is an effective drug to reduce weight in a naturalistic outpatient setting in insulin sensitive and insulin resistant overweight and obese patients. more
    Will metformin cause weight loss?
    Is Metformin an Effective Weight Loss Pill? No. The amount of weight you're likely to lose is low. In one diabetes prevention study, 29% of people lost 5% or more of their body weight and just 8% lost around 10%. more
    Does taking Metformin help with weight loss?
    All things considered, metformin can cause a modest reduction in weight, most likely due to side effects, like a decreased appetite and an upset stomach. But although effective for weight loss, the drug doesn't replace traditional dieting methods. more
    Does metformin 500 mg cause weight loss?
    Is Metformin an Effective Weight Loss Pill? No. The amount of weight you're likely to lose is low. In one diabetes prevention study, 29% of people lost 5% or more of their body weight and just 8% lost around 10%. more
    Does diarrhea from metformin cause weight loss?
    Metformin is generally safe, but common side effects do include vomiting, nausea, and diarrhea. Those experiencing these unpleasant side effects might consume less food, resulting in modest weight reductions. more
    Does metformin cause weight loss?
    Is Metformin an Effective Weight Loss Pill? No. The amount of weight you're likely to lose is low. In one diabetes prevention study, 29% of people lost 5% or more of their body weight and just 8% lost around 10%. more
    Will 500mg of metformin help with weight loss?
    Is Metformin an Effective Weight Loss Pill? No. The amount of weight you're likely to lose is low. In one diabetes prevention study, 29% of people lost 5% or more of their body weight and just 8% lost around 10%. more
    What is better than metformin for weight loss?
    Conclusions: Beinaglutide is more efficient than metformin at reducing weight and fat mass in patients who are overweight/obese and non-diabetic. more

    Source: www.livestrong.com

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