[Originally published: June 28, 2021. Updated: March 1, 2022.]

    Note: Information in this article was accurate at the time of original publication. Because information about COVID-19 changes rapidly, we encourage you to visit the websites of the Centers for Disease Control & Prevention (CDC), World Health Organization (WHO), and your state and local government for the latest information.

    In summer 2021, people were feeling some hope—or at least cautious optimism—that the pandemic could recede to the background, although there was still the threat that new mutations of the  COVID-19 virus  could bring it back, and it might be even stronger.

    That’s when the Delta variant surfaced in the United States. First identified in India in late 2020, Delta swept rapidly through that country and Great Britain before reaching the U.S., where it quickly surged and became the predominant SARS-CoV-2 variant, accounting for  more than 99%  of COVID-19 cases (at the time) and leading to an overwhelming increase in hospitalizations in some states. (Omicron replaced Delta as the predominant variant, but in March 2022, the CDC still included Delta on its list of variants of concern in the U.S., even though it accounted for 0% of cases in the U.S. at that time.)

    Delta was believed to be more than twice as contagious as previous variants, and studies have shown it to be more likely than the original virus to put infected people in the hospital. People who were not vaccinated were most at risk, and the highest spread of cases and severe outcomes happened in places with low vaccination rates.  

    Inci Yildirim, MD, PhD , a Yale Medicine pediatric infectious diseases specialist and a vaccinologist, wasn’t surprised by Delta's progression. “All viruses evolve over time and undergo changes as they spread and replicate,” she said. 

    People who are fully vaccinated against the coronavirus continued to have strong protection against COVID-19 compared to those who weren’t, but there were enough questions about Delta to lead the Centers for Disease Control and Prevention (CDC) to advise additional precautions, including mask guidelines regardless of vaccination status and recommendations for  booster shots . 

    While most Delta infections have been in people who have not had a vaccine, data also showed the variant to have increased transmissibility even among some vaccinated people. 

    Here are five things you need to know about the Delta variant.

    1. Delta is more contagious than the other virus strains.

    The CDC labeled Delta “a  variant of concern ,” using a designation also given to the Alpha strain that first appeared in Great Britain, the Beta strain that first surfaced in South Africa, and the Gamma strain identified in Brazil. (The naming conventions for the variants were established by the World Health Organization [WHO] as an alternative to numerical names.)

    Delta’s quick growth rate was especially dramatic, said  F. Perry Wilson, MD , a Yale Medicine epidemiologist. Delta was spreading 50% faster than Alpha, which was 50% more contagious than the original strain of SARS-CoV-2, he said. “In a completely unmitigated environment—where no one is vaccinated or wearing masks—it’s estimated that the average person infected with the original coronavirus strain will infect 2.5 other people,” Dr. Wilson said. “In the same environment, Delta would spread from one person to maybe 3.5 or 4 other people.”

    “Because of the math, it grows exponentially and more quickly,” he said. “So, what seems like a fairly modest rate of infectivity can cause a virus to dominate very quickly.” 

    2. Unvaccinated people are at risk.

    In the U.S., there was a disproportionate number of unvaccinated people in Southern and Appalachian states, where vaccination rates were low at the time of the Delta surge, but cases rose in other parts of the country as well. In September, health leaders in Idaho, which had one of the lowest vaccination rates in the country, expanded health care rationing throughout the state after the Delta surge led to a scarcity of resources for all hospitalized patients.  

    Children, teenagers, and young adults were a concern, too. “A study from the United Kingdom showed that children and adults under 50 were 2.5 times more likely to become infected with Delta,” said Dr. Yildirim. The U.S. had allowed Pfizer-BioNTech vaccinations for adolescents and teenagers since May 2021, and, in early November, the CDC approved FDA authorization of the Pfizer vaccine for children ages 5-17. 

    3. Delta—and Omicron—and the risk of 'hyperlocal outbreaks.'

    If Delta—and later the Omicron variant—continued to accelerate the pandemic, Dr. Wilson said the biggest questions would be about the heightened transmissibility. The answer could depend, in part, on where you live—and how many people in your location are vaccinated, he said. “I call it ‘patchwork vaccination,’ where you have these pockets that are highly vaccinated that are adjacent to places that have 20% vaccination,” Dr. Wilson said. “The problem is that this allows the virus to hop, skip, and jump from one poorly vaccinated area to another.”

    In some cases, a low-vaccination town that was surrounded by high vaccination areas could end up with the virus contained within its borders, and the result could be “hyperlocal outbreaks,” he said. “Then, the pandemic could look different than what we’ve seen before, where there are real hotspots around the country.”

    So, instead of a three- or four-year pandemic that peters out once enough people are vaccinated, an uptick in cases would be compressed into a shorter period of time. “That sounds almost like a good thing,” Dr. Wilson said. “It’s not.” If too many people are infected at once in a particular area, the local health care system will become overwhelmed, and more people will die, he said. “That’s something we have to worry about a lot.”

    4. There is still more to learn about Delta.

    As data about Delta accumulated, scientists worked hard to learn as much as possible as quickly as possible. One important question was whether the Delta strain could make a person sicker than the original virus. Early information about the severity of Delta included studies from  Scotland  and Canada, both cited by the CDC, that suggested the Delta variant may be more likely to result in hospitalization in the unvaccinated. A report in 2021, published in  The Lancet Infectious Diseases , found that people in England with Delta had double the hospitalization risk of those with Alpha, which was previously the dominant mutation in that country. 

    Another question focused on how Delta affects the body. There have been reports of symptoms that are different than those associated with the original coronavirus strain, Dr. Yildirim said. “It seems like cough and  loss of smell  are less common,” she said. “And headache, sore throat, runny nose, and fever are present based on surveys in the U.K.”

    Meanwhile, experts have continued to study Delta and  breakthrough cases . The CDC has noted that no vaccine is 100% effective, and any rise in cases will have an accompanying rise in breakthrough infections.

    There have been additional questions and concerns about Delta, including  Delta Plus —a subvariant of Delta, that has been found in the U.S., the U.K., and other countries. “Delta Plus has one additional mutation to what the Delta variant has,” said Dr. Yildirim. This mutation, called K417N, affects the spike protein that the virus needs to infect cells, and that is the main target for the mRNA and other vaccines, she said.

    Delta Plus was reported first in India, but the type of mutation was reported in variants such as Beta that emerged earlier,” Dr. Yildirim added.

    5. Vaccination is the best protection against Delta.

    The most important thing you can do to protect yourself from Delta, Omicron, or any COVID-19 variant is to get fully vaccinated, the doctors say. Recommendations for boosters and who is eligible to get one have been changing, and  updated information is available on the CDC website .

    Meanwhile, experts continue to recommend infection prevention strategies , including following its latest guidelines on wearing masks, washing hands, being careful around crowds, social distancing, and testing.

    Note: Information provided in Yale Medicine articles is for general informational purposes only. No content in the articles should ever be used as a substitute for medical advice from your doctor or other qualified clinician. Always seek the individual advice of your health care provider with any questions you have regarding a medical condition.

    Can you get Delta twice?
    Delta was believed to be more than twice as contagious as previous variants, and studies have shown it to be more likely than the original virus to put infected people in the hospital. more
    Which is stronger delta 8 or Delta 9?
    Delta 9 is considerably more potent than Delta 8. Some believe it to be about twice as strong overall. Side effects are also more considerable with Delta 9. These can include paranoid delusions, mental fog, impaired motor skills, and increased feelings of anxiety. more
    Is delta-8 or delta-10 stronger?
    Delta 8 THC is the stronger of the two. Users report a relaxed and sleepy feeling, which makes this cannabinoid great for use in the evenings. Delta 10 THC, on the other hand, is more like a Sativa strain of marijuana. It provides an uplifting feeling. more
    Is delta-8 or delta 10 better?
    Delta 8 has a higher potency than Delta 10. Due to the difference, it can give you mild psychoactive effects. In contrast, Delta 10 is less potent and doesn't give the same intensity of sensations, even though some manufacturers increase the levels of CBN, which is a cannabinoid that has the same effects. more
    Does delta 10 get you higher than delta-8?
    Will delta-8 get you higher than delta-10? Yes. Delta-8 will cause a stronger, more noticeable euphoric high than delta-10. However, neither are as potent as delta-9 THC, which makes them great if you're a beginner user wanting to experience a milder high. more
    Is delta-8 or Delta 9 stronger?
    Delta-9 tetrahydrocannabinol is more potent than delta-8 and accounts for most of the THC that occurs naturally in the cannabis plant, which makes it easy to extract, explaining why it's more commonly smoked. Delta-8-THC, however, is about half as potent. more
    Is delta-8 or Delta 9 better for anxiety?
    Using cannabis for anxiety is a double-edged sword — but not with delta 8 THC. Delta 8 THC is milder than delta 9 THC, which is the main psychoactive ingredient in marijuana. It comes with similar health benefits, but it has a lower incidence of triggering anxiety and paranoia in high doses. more
    Whats stronger Delta 8 or Delta 9?
    Delta-9 tetrahydrocannabinol is more potent than delta-8 and accounts for most of the THC that occurs naturally in the cannabis plant, which makes it easy to extract, explaining why it's more commonly smoked. Delta-8-THC, however, is about half as potent. more
    Is Delta 10 or delta 9 stronger?
    Compared to delta 9, delta 10 THC offers a much milder experience. To get the same intensity of effects from delta 10 THC requires approximately double the dose. Keep in mind that the effects of delta 10 THC are not the same as delta 9, so start slow and see how you react before taking a large amount. more
    Is delta-8 or Delta 9 better?
    Delta 9 is considerably more potent than Delta 8. Some believe it to be about twice as strong overall. Side effects are also more considerable with Delta 9. These can include paranoid delusions, mental fog, impaired motor skills, and increased feelings of anxiety. more
    What is stronger Delta 9 or delta 8?
    Delta 9 is considerably more potent than Delta 8. Some believe it to be about twice as strong overall. Side effects are also more considerable with Delta 9. These can include paranoid delusions, mental fog, impaired motor skills, and increased feelings of anxiety. more

    Source: www.yalemedicine.org

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