World J Gastroenterol . 2003 Nov;9(11):2565-9. doi: 10.3748/wjg.v9.i11.2565.

    Authors

    Affiliation

    • PMID: 14606098
    • PMCID: PMC4656542
    • DOI: 10.3748/wjg.v9.i11.2565

    Abstract

    Aim: To observe the therapeutic efficacy of high-dose Vitamin C (Vit. C) on acute pancreatitis (AP), and to explore its potential mechanisms.

    Methods: Eighty-four AP patients were divided into treatment group and control group, 40 healthy subjects were taken as a normal group. In the treatment group, Vit. C (10 g/day) was given intravenously for 5 days, whereas in the control group, Vit. C (1 g/day) was given intravenously for 5 days. Symptoms, physical signs, duration of hospitalization, complications and mortality rate were monitored. Meanwhile, serum amylase, urine amylase and leukocyte counts were also determined. The concentration of plasma vitamin C (P-VC), plasma lipid peroxide (P-LPO), plasma vitamin E (P-VE), plasma beta-carotene (P-beta-CAR), whole blood glutathione (WB-GSH) and the activity of erythrocyte surperoxide dimutase (E-SOD) and erythrocyte catalase (E-CAT) as well as T lymphocyte phenotype were measured by spectrophotometry in the normal group and before and after treatment with Vit. C in the treatment and the control group.

    Results: Compared with the normal group, the average values of P-VC, P-VE, P-beta-CAR, WB-GSH and the activity of E-SOD and E-CAT in AP patients were significantly decreased and the average value of P-LPO was significantly increased, especially in severe acute pancreatitis (SAP) patients (P<0.05. P-VC, P=0.045; P-VE, P=0.038; P=0.041; P-beta-CAR, P=0.046; WB-GSH, P=0.039; E-SOD, P=0.019; E-CAT, P=0.020; P-LPO, P=0.038). Compared with the normal group, CD3 and CD4 positive cells in AP patients were significantly decreased. The ratio of CD4/CD8 and CD4 positive cells were decreased, especially in SAP patients (P<0.05. CD4/CD8, P=0.041; CD4, P =0.019). Fever and vomiting disappeared, and leukocyte counts and amylase in urine and blood become normal quicker in the treatment group than in the control group. Moreover, patients in treatment group also had a higher cure rate, a lower complication rate and a shorter in-ward days compared with those in he control group. After treatment, the average value of P-VC was significantly higher and the values of SIL-2R, TNF-alpha, IL-6 and IL-8 were significantly lower in the treatment group than in the control group (P<0.05 P-VC, P=0.045; SIL-2R, P=0.012; TNF-alpha, P=0.030; IL-6, P=0.015; and IL-8, P=0.043). In addition, the ratio of CD4/CD8 and CD4 positive cells in the patients of treatment group were significantly higher than that of the control group after treatment (P<0.05. CD4/CD8, P=0.039; CD4, P=0.024).

    Conclusion: High-dose vitamin C has therapeutic efficacy on acute pancreatitis. The potential mechanisms include promotion of anti-oxidizing ability of AP patients, blocking of lipid peroxidation in the plasma and improvement of cellular immune function.

    Publication types

    • Clinical Trial
    • Comparative Study
    • Controlled Clinical Trial

    MeSH terms

    • Acute Disease
    • Adult
    • Aged
    • Antioxidants / administration & dosage*
    • Ascorbic Acid / administration & dosage*
    • Cytokines / blood
    • Female
    • Humans
    • Immunity, Cellular / drug effects
    • Injections, Intravenous
    • Lipid Peroxidation / drug effects
    • Male
    • Middle Aged
    • Pancreatitis / drug therapy*
    • Pancreatitis / immunology
    • Pancreatitis / metabolism*

    Substances

    • Antioxidants
    • Cytokines
    • Ascorbic Acid
    Does vitamin C help pancreatitis?
    CONCLUSION: High-dose vitamin C has therapeutic efficacy on acute pancreatitis. The potential mechanisms include promotion of anti-oxidizing ability of AP patients, blocking of lipid peroxidation in the plasma and improvement of cellular immune function. more
    Can I take vitamin B12 and vitamin D3 together?
    Interactions between your drugs. No interactions were found between Vitamin B12 and Vitamin D3. more
    Which is better vitamin D or vitamin D3?
    There are two possible forms of vitamin D in the human body: vitamin D2 and vitamin D3. Both D2 and D3 are simply called “vitamin D,” so there's no meaningful difference between vitamin D3 and just vitamin D. more
    Can you take vitamin B12 and Vitamin C together?
    Taking vitamin B-12 with vitamin C might reduce the available amount of vitamin B-12 in your body. To avoid this interaction, take vitamin C two or more hours after taking a vitamin B-12 supplement. more
    Is Vitamin D good for pancreatitis?
    This has been demonstrated by studies showing that vitamin D deficiency is associated with pancreatitis and its anti-inflammatory and anti-fibrotic effects by binding with the vitamin D receptor (VDR). more
    Can vitamin D3 cause pancreatitis?
    The increase made pancreatitis worse. The low levels of circulating vitamin D2 and D3 are part of the body's response to the elevated 1,25-dihydroxy vitamin D. Vitamin D supplementation is thus not usually done in pancreatitis since it can make it worse. more
    What vitamin helps you absorb vitamin D?
    Combining vitamin D with magnesium may also help to increase absorption. Foods that are naturally high in magnesium include: Pumpkin seeds. more
    Is vitamin D3 the same as vitamin D?
    There are two possible forms of vitamin D in the human body: vitamin D2 and vitamin D3. Both D2 and D3 are simply called “vitamin D,” so there's no meaningful difference between vitamin D3 and just vitamin D. more
    Is vitamin D2 better than vitamin D3?
    Studies have repeatedly shown that vitamin D3 is superior at raising levels of vitamin D in the body. These findings were supported by a recent review of the evidence which found that vitamin D3 supplementation increased vitamin D levels in the body better than vitamin D2. more
    Which is better vitamin B complex or vitamin B12?
    When it comes to the issue of vitamin B12 vs B complex, both types of vitamins are crucial. If you're lacking B12, consume more of it via supplements or food. If you're lacking vitamin B in general, consider B complex vitamins instead. Overall, both vitamins are essential nutrients. more
    Can taking vitamin D cause pancreatitis?
    The increase made pancreatitis worse. The low levels of circulating vitamin D2 and D3 are part of the body's response to the elevated 1,25-dihydroxy vitamin D. Vitamin D supplementation is thus not usually done in pancreatitis since it can make it worse. more

    Source: pubmed.ncbi.nlm.nih.gov

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