1. Home
    2. News

    Two brain chemicals may interact to contribute to the development of psychotic disorders such as schizophrenia, according to a new study.

    The results suggest abnormal levels of the neurotransmitter glutamate may lead to changes in the levels of another neurotransmitter, dopamine , causing the transition into psychosis. Though both chemicals have been studied before, the interaction between them has been brought to light by the new study, the researchers say.

    Targeting this interaction may be a way to treat these mental disorders and possibly prevent them from occurring, the researchers say.

    "If we could prevent this kind of abnormal glutamate-dopamine interaction early enough in the illness, it might prevent people from actually going on to get full blown psychosis," said study researcher James Stone, of King's College London in the United Kingdom.

    Dopamine and glutamate

    Scientists have long known that dopamine is involved in the development of schizophrenia and other psychotic disorders. People with schizophrenia have an overactive dopamine system, releasing more dopamine than healthily people. Currently, the drugs used to treat schizophrenia aim to regulate dopamine levels in the brain.

    But scientists say dopamine doesn't tell the whole story. Some people with schizophrenia don't respond to dopamine-regulating drugs, Stone said. And most of the genes that have been linked to schizophrenia are involved in the production or regulation of glutamate, not dopamine. Drugs such as PCP that act on the glutamate system produce symptoms similar to those seen in schizophrenia.

    Previous studies have shown schizophrenia patients have changes in their glutamate systems, but no one had looked at how glutamate and dopamine interact in the same person.

    Stone and his colleagues examined images of the brains of 16 individuals who had some psychotic symptoms, but whose symptoms were not intense enough for them to be diagnosed with schizophrenia. Instead, they have an illness known as "at-risk mental state for psychosis," and are known to be at risk for developing schizophrenia later on. These brain images were compared to those of 12 healthily volunteers.

    In the "at risk" patients, low glutamate levels in one part of the brain, called the hippocampus, were associated with increased dopamine activity in another brain area called the striatum.

    This relationship was not seen in the healthy volunteers.

    "This suggests that these people have something abnormal in terms of their glutamate-dopamine interactions," Stone told MyHealthNewsDaily.

    Schizophrenia drugs

    The results provide more evidence that glutamate is indeed involved in the development of schizophrenia, Stone said.

    And the study supports the idea that drugs for schizophrenia that target glutamate as well dopamine should be developed.

    It's possible that future research may lead to a way to use these chemical abnormalities, in addition to genetic testing, as risk markers for schizophrenia, Stone said.

    The study is published in the October issue of the journal Biological Psychiatry.  

    Rachael has been with Live Science since 2010. She has a master's degree in journalism from New York University's Science, Health and Environmental Reporting Program. She also holds a B.S. in molecular biology and an M.S. in biology from the University of California, San Diego. Her work has appeared in Scienceline, The Washington Post and Scientific American.

    What chemicals can cause psychosis?
    Drugs known to trigger psychotic episodes include:
    • cocaine.
    • amphetamine (speed)
    • methamphetamine (crystal meth)
    • mephedrone (MCAT or miaow)
    • MDMA (ecstasy)
    • cannabis.
    • LSD (acid)
    • psilocybins (magic mushrooms)
    more
    How did pirates get their names?
    When Bierbauer didn't sign back with Philadelphia as expected, however, Pittsburgh drew criticism from the Athletics and American Association officials who called those actions “piratical.” Accused of plundering players, the Alleghenys then became known informally as “pirates.” Pittsburgh officially nicknamed itself more
    Is the Zeus armor good?
    1 Zeus Armor Set The Zeus Armor Set is, without a doubt, the best armor set in the entire game. It's also the most dangerous and hardest to obtain since you'll need to defeat all the Valkyries in New Game Plus. more
    What was Elsa's last words on 1883?
    Elsa Dutton and James Dutton seemingly sat for hours beneath the tree in 1883 episode 10. It's clear to both of them that Elsa will die under that tree. When she finally starts to go, she has a few final words for her father after seeing a bird. “You birds sure are smart,” Elsa says to the bird. more
    What is Yoongi's dog?
    Min Holly Min Holly (민홀리) or Holly (홀리) is a brown "Toy Poodle" dog that belongs to Suga. more
    Do ear mites smell in dogs?
    Mite infestations can cause a foul odor in your dog's ears. You may also see a buildup of dark debris in your dog's ears, similar to coffee grounds. As you examine your dog's ears, look for redness in the ear canal as well as the outer ear, as this is another sign of ear problems in dogs. more
    Why do Bulldogs choke?
    Brachycephalic Obstructive Airway Syndrome These dogs are born with a soft palate that obstructs airflow into their lungs. Your bulldog will have difficulty in breathing and will retch or gag especially while swallowing. more
    How much do you get for 1 million views on TikTok?
    TikTok pays content creators $0.02–$0.04 per every 1,000 views. This means you'll get about $15 for 500,000 views and $40-$50 for 1 million views. It sounds insane—we know—especially when compared to YouTube, which pays between $2,000 and $4,000 for a million views. more
    Why did the Mongols drink blood?
    While everyone likes to talk about how scary the Spartans or Romans could be, it was the Mongols who pioneered new warfare tactics, used them to win battle after battle, and survived on a diet of horse blood and liquor to ride across whatever terrain they needed to in order to murder you. more
    How long should you hold your bearded dragon?
    You can hold a bearded dragon for as long as it will tolerate being held. Start with 15 minutes once a day and as it gets used to being handled, you can hold it longer. Some dragons enjoy being held several times a day for several hours. When the beardie becomes restless, it is time to put him back. more
    What is the most common full name in Canada?
    Smith Canada (Canadian) more

    Source: www.livescience.com

    You may be interested in...

    Do you eat the whole snap pea?

    What is liquidity mining pool?

    What is the rarest subtype of ADHD?

    Is riding a horse animal cruelty?

    Who changes the price of a stock?

    What is the smallest ethnic group in Africa?

    Which trait of a household worker exercises sound decision making skills when needed?

    How can I use leftover coffee grounds?

    Can I buy a house and put it in my child's name?

    Can autism be detected in vitro?

    Does Binance have instant withdrawal?

    What climate is healthiest?

    Why are the leaves on my snow peas turning yellow?

    What food should not go down the drain?

    Is BCom necessary for banking?

    About Privacy Contact
    ©2022 REPOKIT