In our previous posts on vitamin D we've discussed how to get your serum D level checked, how much D you need to include in your diet - either through supplement, foods or sun - how much sun you need to get to produce a substantial amount of D and many other topics.

    One thing we haven't discussed is the medications that could interfere with the absorption of vitamin D.

    The current recommended daily allowance for D appears to be low according to the many vitamin D researchers that are experts in this field of study. We know that we are in the midst of a vitamin D deficiency epidemic, and that we need to take pro-active steps to rectify this crisis.

    Since we are all trying our best to get the right amount of D I think it's important to know that some medications can inhibit the absorption of D and we wanted to give you a list of those medications.

    Below is a list of medications that interfere with the absorption of D which could cause further deficiencies than what we are already dealing with. Since the correct amount of D is so essential for the treatment of bone loss and many other health concerns like cancer, heart disease, arthritis, diabetes, and autoimmune diseases; it seems to me to be very important to know if we are taking something that would further complicate our daily routine of getting the proper amount of D.

    Drugs That Affect the Absorption of Vitamin D

    • Aluminum or Magnesium containing antacids

    • Thiazide and similar diuretics

    • Anticonvulsants (Carbamazepine®)

    • St. John's wort

    • Antiretrovirals (AIDS therapies)

    • Alcohol

    • Antirejection medications (after organ transplant)

    • Mineral Oil (may influence hypocalcemia)

    • Barbiturates (Phenobarbital®)

    • Stimulant laxatives

    • Cholestyramine® and Colestipol® (anticholesterol agents)

    • Tobacco

    • Corticosteroids and Glucocorticoids

    • Hydroxychloroquine (Plaquenil®)

    • Digoxin®

    • Rifampin® (bactericidal antibiotic)

    • Digitalis®

    Note that these items may affect the absorption of vitamin D, but your Doctor can adjust your vitamin D dose to correct this malabsorption. Conversely, vitamin D doesn't affect the actions of these drugs on the body, so vitamin D has no deleterious affect on the above medications and their benefits.

    If you are taking one of these medications with vitamin D, check with your Doctor to see if there needs to be an adjustment in the amount of D you take with these drugs.

    Important Note: Patients with hypercalcemia should avoid prescribed high doses of vitamin D.

    I hope this information helps you to gain the full amount of vitamin D that you take without causing any vitamin D malabsorption or adjustment.

    Meet Our Writer

    Pam Flores

    Pam wrote for HealthCentral as a patient expert for Osteoporosis.

    What medications affect vitamin D absorption?
    Steroids. Taking steroid mediations such as prednisone can reduce calcium absorption and impair your body's processing of vitamin D. Stimulant laxatives. Long-term use of high doses of stimulant laxatives can reduce vitamin D and calcium absorption. more
    Does vitamin D affect memory?
    Conclusions. Our findings suggest an association between severe vitamin D deficiency and visual memory decline but no association with verbal memory decline. more
    Does vitamin B affect prostate?
    [21], in a study conducted in Sweden, observed that vitamin B 12 supplementation was associated with an up to threefold increase in the risk of prostate cancer. more
    Do antibiotics affect vitamin absorption?
    They can deplete nutrients- especially micronutri- ents - minerals, vitamin k and B12. Antibiotic also affects affect gut motility, transit time and colon processes. Food components like fat, fiber and carbohydrates digestion, absorption can be affected. more
    Does vitamin D3 affect sleep?
    An intervention study reported that vitamin D supplementation (D3) in veterans (50,000 IU/week) increased their sleep duration [56]. Another double-blind clinical trial showed use of vitamin D supplementation (50,000 IU/fortnight for 8 weeks) facilitated sleep duration and quality in people with sleep disorder [61]. more
    Does vitamin D affect prostate?
    We found that variations in one gene related to vitamin D level were associated with an increased risk of prostate cancer in men with deficient vitamin D levels. Men who tended to burn (rather than tan) were more likely to have lower circulating vitamin D and to have prostate cancer. more
    Does atorvastatin affect vitamin D?
    Atorvastatin treatment produced a statistically significant decrease in cholesterol and triglyceride levels and an increase in vitamin D levels (41+/-19 vs 47+/-19 nmol/L, p=0.003). Vitamin D deficiency was decreased by 75% to 57% at 12 months. In conclusion, atorvastatin increases vitamin D levels. more
    Does vitamin D affect B12?
    There was a significant relationship between vit D deficiency and vit B12 deficiency. In conclusion, vit B12 deficiency is common in school-age children, especially in the adolescent age group. It should be known that vit D deficiency may also be present in vit B12 deficiency cases. more
    Can vitamin D affect sleep?
    Being deficient in vitamin D can lead to a host of sleep issues, including sleep disruption, insomnia, and overall poor sleep quality. "A deficiency in Vitamin D has been associated with many changes in sleep such as fewer sleeping hours, and sleep that is less restful and restorative," said Dr. more
    Does sugar affect vitamin D?
    VITAMIN D - A high intake of sugar, particularly fructose, increases the production of a devious enzyme which degrades stores of vitamin D. It can also undermine the production of another enzyme necessary to synthesize this critical nutrient. more
    Does vitamin D affect energy?
    Low energy or fatigue is a common symptom of vitamin D deficiency. That's because vitamin D seems to help mitochondria—the part of a cell that generates energy—use oxygen and power various parts of the body, including muscles. Large studies on otherwise healthy people taking a daily vitamin D supplement are lacking. more


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