Last updated October 13, 2021. Edited and medically reviewed by Patrick Alban, DC . Written by Deane Alban .
There are many kinds of prescription drugs and OTC medications that cause memory loss. See if any drugs you take can cause problems and what to do about it.
According to Harvard University, prescription drugs cause over 128,000 deaths per year in the United States.
This does not count deaths in nursing homes which account for another estimated additional 350,000 deaths annually.
Adverse drug reactions are now the fourth leading cause of death in the US and the fifth leading cause of hospital death in Europe.
More emergency room visits result from prescription medications than from illicit drugs, alcohol, and recreational drug use combined .
It’s very clear that medications carry significant risks and one of the most common risks is memory loss.
If you take any prescription medications that are affecting your memory, it likely falls into one of three major categories of drugs known to cause memory loss and other cognitive problems: anticholinergics, sleeping pills, or cholesterol-lowering drugs.
Here’s an in-depth look at each.
Acetylcholine is the primary neurotransmitter of memory and learning.
When you’re low in acetylcholine, you become forgetful and can’t concentrate.
You may struggle to find the right words when you speak.
Acetylcholine deficiencies are associated with dementia and Alzheimer’s; medications for these disorders work by preventing the breakdown of acetylcholine in the brain.
" Not all drugs that cause memory loss are prescription medications. Many popular over-the-counter (OTC) drugs also cause memory loss by blocking the neurotransmitter acetylcholine.
Drugs that block the action of acetylcholine, causing low brain levels of acetylcholine, are known as anticholinergics .
Mind Lab Pro WHAT'S THE BEST BRAIN SUPPLEMENT?
We hear this question often. Here's our answer:
#1 Live a brain-healthy lifestyle first (Be Brain Fit tells you how).
#2 Give Mind Lab Pro a try.
This brain supplement meets all 12 of my requirements for a high-quality brain supplement, including effectiveness, safety, purity, and value. So it's easier for you to be mentally sharper, happier, and more productive.
Choosing the right brain supplement is all about quality. Now, buy a 3-month supply (3 boxes) of Mind Lab Pro & get 1 month free. This 25% discount includes free shipping worldwide. See why I recommend Mind Lab Pro.
It’s easy to pick out many drugs that are anticholinergics because their common classifications usually start with “anti” as in:
Common side effects of anticholinergic drugs include:
Low acetylcholine can lead to a cluster of symptoms that resembles dementia, including mental confusion, brain fog, incoherent speech, delirium, blurred vision, memory loss, and hallucinations.
The side effects of anticholinergic drugs are more pronounced in seniors due to the natural decline in acetylcholine production that occurs with age.
You can take a look at the list created by The Peoples Pharmacy or download a PDF created by the Indiana University Center for Aging Research .
Not all anticholinergic drugs are equally hazardous, so these lists rate drugs by their level of anticholinergic activity — mild, moderate, or severe.
Leo Galland, MD, a renowned functional medicine pioneer, has published an extensive list of anticholinergic substances that includes drugs and herbal remedies.
Additionally, you can check all the medications you are currently taking to determine your anticholinergic burden with this physician-created online calculator .
If your anticholinergic risk is high, we urge you to bring this to your doctor’s attention.
Prescription sleeping pills like Ambien, Sonata, and Lunesta are notorious for causing memory problems.
Ever since these drugs came on the market, people have been reporting “Ambien amnesia” or “Ambien blackouts” during which they have walked, eaten, and even driven their car in their sleep with no recollection of it the following day!
Kirk Parsley, MD, is a physician, former Navy SEAL, and a sleep expert for the US Navy.
He found that a large number of Navy SEALs were using sleeping pills and made a startling discovery while studying EEGs of their brains.
Brainwave patterns showed that, under the effect of sleeping pills, these men were unconscious but not actually asleep; it was as if they were drunk or in a coma.
According to Dr. Parsley’s observations, this means that these men were not experiencing the restorative sleep their brains needed to consolidate new memories and to maintain and repair itself.
Cholesterol-lowering medications might just be the single worst group of drugs for your brain.
Memory loss is now required to be listed as a side effect on the label of cholesterol-lowering drugs, like Lipitor and Crestor, known as statins.
When researchers examined the medical records of nearly a million people, they found that statin use increased the risk of memory loss four-fold .
And it’s not just statins, other kinds of cholesterol-lowering drugs are also strongly linked to increased forgetfulness.
Here’s why lowering cholesterol is a problem for your brain.
Your brain is 60% fat by dry weight and contains 25% of your body’s total cholesterol .
Cholesterol is necessary for memory, learning, and fast thinking.
It is needed to synthesize neurotransmitters , chemicals that brain cells use to communicate with each other.
So it is not such a surprise that cholesterol-lowering drugs negatively affect the brain.
And some research has found that high total cholesterol reduces the risk of dementia in the elderly.
You read that right.
Statins have been pushed on the public because they are among the most profitable prescription drugs in the world.
One in two senior men and one in three senior women are prescribed these drugs .
And if drug companies have their way, even more people will be prescribed statins in the future.
US Preventive Services Task Force guidelines recommend that everyone over the age of 40 should be screened for taking a statin drug even if they have no history of heart disease.
Our Brain PowerUp Guide is yours FREE when you subscribe to our world-class information on brain health & performance.
Richard C. Mohs, PhD, is the Chief Scientific Officer for the Global Alzheimer’s Platform Foundation .
He is the author of more than 350 scientific papers, including those involving clinical trials that led to the approval of cholinergic drugs for treating Alzheimer’s disease.
According to Dr. Mohs, additional medications known to cause memory loss include:
Not all drugs that cause memory loss are prescription medications.
Many popular over-the-counter (OTC) drugs also cause memory loss by blocking the neurotransmitter acetylcholine.
These are some common anticholinergic OTC remedies known to cause memory loss:
A large study found that seniors who take OTC medications are at significantly increased risk for developing dementia and Alzheimer’s.
Performance Lab NUTRITION FOR YOUR MIND
It’s almost impossible to live a lifestyle that provides all the nutrients needed for good brain health and performance. The reason? All of us confront multiple nutrient thieves — stress, poor diet, insomnia, pharmaceuticals, pollution, and more — that steal nutrients that the brain needs to thrive.
Taking quality nutritional supplements:
A foundational principle of mental health and cognitive performance is to supply the brain with the best nutrition possible. Now, buy a 3-month supply (3 boxes) of any Performance Lab supplement & get 1 month free. This 25% discount includes free shipping worldwide. See why I recommend Performance Lab.
Long-term use is not required.
Memory loss from these remedies was noticeable in as little as 60 days.
This is bad news for the millions of people who rely on diphenhydramine, the generic name for Benadryl , to treat allergies, colds, and insomnia.
Many OTC remedies for allergies, colds, cough, sinus problems, skin irritations, insomnia, headache, and pain contain diphenhydramine.
You can find a complete list of OTC medicines that contain diphenhydramine at Drugs.com .
Are you taking any of these prescription medications?
Do you suspect that they are affecting your memory?
Then we recommend following the advice of Armon B. Neel, Jr, PharmD, CGP, FASCP.
He is a geriatric pharmacist who has devoted his career to guiding health professionals and older adults in the appropriate use of medication.
He previously was the author of AARP’s “Ask a Pharmacist” column and is the author of the eye-opening exposé Are Your Prescriptions Killing You?
Take inventory of what you are taking.
Write down every medication, dosage, and when you started taking it.
Talk to your doctor about what you are taking, how much you are taking, and why you are taking it.
If you have more than one physician, have this conversation with each of them.
Ask if there are any non-drug approaches that you can use instead.
Find out the consequences of stopping any medication.
If there are any medications that can be eliminated, discuss a plan for stopping them and follow the plan.
You should always get all your medications filled by the same pharmacy.
Talk to your pharmacist about everything you take to make sure that there are no known interactions.
In the meantime, you can check for interactions right now using one of the online drug interaction checkers in our Mental Health Resources Guide .
Read Are Your Prescriptions Killing You? .
Reviewers on Amazon call it “indispensable knowledge” and “a lifesaver.”
If you are a senior, consider enlisting the help of a senior care pharmacist, also called a consultant pharmacist.
Senior care pharmacists are specially trained to review their patient’s medications to ensure appropriate, effective, and safe use.
You can find one in your area through the American Society of Consultant Pharmacists .
Lastly, use the lifestyle advice for brain health that’s here on Be Brain Fit.
Even if you must stay on all your medications, you can help your brain by taking proactive steps such as:
If you regularly take an OTC medicine for allergies, pain, insomnia, or acid reflux, get serious about switching to natural remedies which can provide relief — without increasing your risk of dementia.
Give your brain the healthiest possible environment to stay mentally sharp, in spite of your medications.
Prescription medications are a double-edged sword.
Obviously, they are sometimes needed, but doctors are often too eager to write prescriptions for drugs that can affect memory and other cognitive skills.
Become an educated patient and understand exactly what you are taking, why you are taking it, and the risks involved.
Be proactive about talking to your doctor and your pharmacist if you believe your prescriptions, or OTC remedies, are causing memory loss.
Recommended: Upgrading brain health is key to making your brain work better.
Mind Lab Pro is the brain supplement we recommend because, by boosting your brain health, it can help you:
See our MIND LAB PRO review.